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Tbio
STX2
Syntaxin-2

Protein Summary
Description
Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261653
  • ENSP00000261653
  • ENSG00000111450
  • ENST00000392373
  • ENSP00000376178

Symbol
  • EPIM
  • STX2A
  • STX2B
  • STX2C
  • EPM
  • EPIM
  • STX2A
  • STX2B
  • STX2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.98
histone modification site profile
0.82
protein domain
0.73
cellular component
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1417.07   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1417.07   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
1
1
2
73.7
tissue plasminogen activator measurement
2
2
2
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
73.7
tissue plasminogen activator measurement
2
62.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 2
VGNC:5606
737801
Macaque
syntaxin 2
718628
Mouse
MGI:108059
13852
Rat
RGD:2558
25130
Dog
syntaxin 2
VGNC:49890
477439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 2
Macaque
syntaxin 2
Mouse
Rat
Dog
syntaxin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P32856-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (130)
1 – 10 of 130
SNAP23
Tbio
Novelty: 0.0065371
Score: 0.999
Data Source: STRINGDB
VAMP2
Tbio
Novelty: 0.00187736
Score: 0.999
Data Source: STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
Score: 0.999
Data Source: STRINGDB
VAMP3
Tbio
Novelty: 0.00694332
Score: 0.999
Data Source: STRINGDB
STXBP1
Tbio
Novelty: 0.00339098
Score: 0.975
Data Source: STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.97
Data Source: STRINGDB
ST8SIA2
Tbio
Family: Enzyme
Novelty: 0.00073008
Score: 0.935
Data Source: STRINGDB
VAMP7
Tbio
Novelty: 0.00900603
Score: 0.926
Data Source: STRINGDB
STX6
Tbio
Novelty: 0.01494028
Score: 0.924
Data Source: STRINGDB
STX16
Tbio
Novelty: 0.02462523
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  1417.07

PubMed score by year
PubTator Score  292.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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