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Tbio
MYO1B
Unconventional myosin-Ib

Protein Summary
Description
Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304164
  • ENSP00000306382
  • ENSG00000128641
  • ENST00000339514
  • ENSP00000341903
  • ENST00000392318
  • ENSP00000376132

Symbol
  • MMIa
  • myr1
  • MYH-1c
  • MMI-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.96
virus perturbation
0.94
disease perturbation
0.93
PubMedID
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.09   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.09   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
0
3.7
54.2
neutrophil count
2
2
2
48.5
myeloid white cell count
1
1
1
10.6
smoking status measurement
1
1
1
5.9
reticulocyte measurement
2
1
2
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
0
3.7
54.2
neutrophil count
2
48.5
myeloid white cell count
1
10.6
smoking status measurement
1
5.9
reticulocyte measurement
2
3.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin IB
VGNC:14315
459835
Macaque
myosin IB
694510
Mouse
MGI:107752
17912
Rat
RGD:70994
117057
Dog
myosin IB
VGNC:43561
478846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin IB
Macaque
myosin IB
Mouse
Rat
Dog
myosin IB
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43795-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (53)
1 – 10 of 53
NEXN
Tbio
Novelty: 0.00745011
p_int: 0.98827433
p_ni: 0.01172567
Score: 0.264
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.983271599
p_ni: 0.016728401
Data Source: BioPlex
TNNC1
Tclin
Novelty: 0.03535727
p_int: 0.955429284
p_ni: 0.044570717
Score: 0.192
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.893167887
p_ni: 0.106832113
Score: 0.188
Data Source: BioPlex,STRINGDB
AVIL
Tbio
Novelty: 0.0175973
p_int: 0.86820331
p_ni: 0.13179669
Score: 0.223
Data Source: BioPlex,STRINGDB
LSP1
Tbio
Novelty: 0.00889927
p_int: 0.853529946
p_ni: 0.146470054
Score: 0.272
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.848137305
p_ni: 0.151862695
Score: 0.236
Data Source: BioPlex,STRINGDB
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.84027101
p_ni: 0.15972899
Score: 0.352
Data Source: BioPlex,STRINGDB
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.761
Data Source: STRINGDB
ALPK1
Tbio
Family: Kinase
Novelty: 0.04419259
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  138.09

PubMed score by year
PubTator Score  58.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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