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Tbio
C19orf12
Protein C19orf12

Protein Summary
Description
This gene encodes a small transmembrane protein. Mutations in this gene are a cause of neurodegeneration with brain iron accumulation-4 (NBIA4), but the specific function of the encoded protein is unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323670
  • ENSP00000313332
  • ENSG00000131943
  • ENST00000392276
  • ENSP00000376102
  • ENST00000392278
  • ENSP00000376103
  • ENST00000592153
  • ENSP00000467117
  • ENST00000614091
  • ENSP00000482097
  • ENST00000623113
  • ENSP00000485413

Symbol
  • MPAN
  • NBIA3
  • NBIA4
  • SPG43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.59   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.59   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway
Name
Explore in Pharos
Explore in Source
Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (44)
1 – 10 of 44
PANK2
Tbio
Family: Kinase
Novelty: 0.00556645
Score: 0.802
Data Source: STRINGDB
FA2H
Tbio
Family: Enzyme
Novelty: 0.006234
Score: 0.766
Data Source: STRINGDB
WDR45
Tbio
Novelty: 0.02244727
Score: 0.76
Data Source: STRINGDB
PANK1
Tbio
Family: Kinase
Novelty: 0.01345967
Score: 0.739
Data Source: STRINGDB
DCAF17
Tbio
Novelty: 0.03944341
Score: 0.735
Data Source: STRINGDB
PLA2G6
Tchem
Family: Enzyme
Novelty: 0.00258089
Score: 0.73
Data Source: STRINGDB
VSTM2B
Tdark
Novelty: 2.55319149
Score: 0.697
Data Source: STRINGDB
ATP13A2
Tbio
Family: Transporter
Novelty: 0.00798599
Score: 0.67
Data Source: STRINGDB
MIGA1
Tbio
Novelty: 0.11180124
Score: 0.658
Data Source: STRINGDB
MFSD6
Tbio
Novelty: 0.02839266
Score: 0.657
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.59

PubMed score by year
PubTator Score  29.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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