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Tbio
BCAS3
Breast carcinoma-amplified sequence 3

Protein Summary
Description
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390652
  • ENSP00000375067
  • ENSG00000141376
  • ENST00000407086
  • ENSP00000385323
  • ENST00000408905
  • ENSP00000386173
  • ENST00000588462
  • ENSP00000468592
  • ENST00000588874
  • ENSP00000464825
  • ENST00000589222
  • ENSP00000466078

Symbol
  • MAAB
  • GAOB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
trait
0.93
histone modification site profile
0.89
transcription factor binding site profile
0.85
phenotype
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.24   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.24   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
11
14
98.2
glomerular filtration rate
10
5
13
14.9
96.5
urate measurement
4
2
5
95.2
intraocular pressure measurement
4
5
5
93.3
optic disc size measurement
2
2
2
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
14
98.2
glomerular filtration rate
13
14.9
96.5
urate measurement
5
95.2
intraocular pressure measurement
5
93.3
optic disc size measurement
2
92.7
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (94)
1 – 10 of 94
C16orf70
Tdark
Novelty: 2.12573065
p_int: 0.999995956
p_ni: 0.000004044
Score: 0.824
Data Source: BioPlex,STRINGDB
WIPI2
Tbio
Novelty: 0.02685992
p_int: 0.999994267
p_ni: 0.000005733
Score: 0.876
Data Source: BioPlex,STRINGDB
MAGEE1
Tbio
Novelty: 0.10759081
p_int: 0.998533292
p_ni: 0.001466708
Score: 0.71
Data Source: BioPlex,STRINGDB
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.901568961
p_ni: 0.098431039
Data Source: BioPlex
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.888387086
p_ni: 0.111612914
Score: 0.151
Data Source: BioPlex,STRINGDB
VWA5A
Tbio
Novelty: 0.0802354
p_int: 0.810913489
p_ni: 0.189086402
p_wrong: 1.09e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
RAB2B
Tdark
Family: Enzyme
Novelty: 0.18567584
p_int: 0.779306834
p_ni: 0.220693166
Score: 0.177
Data Source: BioPlex,STRINGDB
BCAS4
Tbio
Novelty: 0.11759439
Score: 0.906
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.902
Data Source: STRINGDB
ANKS1A
Tbio
Novelty: 0.01972212
Score: 0.692
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.24

PubMed score by year
PubTator Score  14.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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