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Tclin
HCAR2
Hydroxycarboxylic acid receptor 2

Protein Summary
Description
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328880
  • ENSP00000375066
  • ENSG00000182782

Symbol
  • GPR109A
  • HCA2
  • HM74A
  • NIACR1
  • HCA2
  • HM74a
  • HM74b
  • PUMAG
  • NIACR1
  • Puma-g
  • GPR109A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.76
chemical
0.63
cell line
0.62
biological process
0.57
biological term
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.78   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.78   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 132
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
10.7
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hydroxycarboxylic acid-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Hydroxycarboxylic acid-binding receptors
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (250)
1 – 10 of 250
HCAR3
Tchem
Family: GPCR
Novelty: 0.03941169
Score: 0.971
Data Source: STRINGDB
PYY
Tbio
Novelty: 0.00060997
Score: 0.936
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.925
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.925
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.922
Data Source: STRINGDB
SUCNR1
Tchem
Family: GPCR
Novelty: 0.01482891
Score: 0.919
Data Source: STRINGDB
BDKRB2
Tclin
Family: GPCR
Novelty: 0.00335227
Score: 0.919
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.918
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.916
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  211.78

PubMed score by year
PubTator Score  96.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer