You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UVSSA
UV-stimulated scaffold protein A

Protein Summary
Description
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex, and is thought to be involved in the transcription-coupled nucleotide excision repair ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389851
  • ENSP00000374501
  • ENSG00000163945
  • ENST00000507531
  • ENSP00000421741
  • ENST00000511216
  • ENSP00000425130
  • ENST00000511563
  • ENSP00000423340
  • ENST00000512728
  • ENSP00000427701

Symbol
  • KIAA1530
  • UVSS3
  • KIAA1530
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.8
tissue sample
0.67
tissue
0.59
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.29   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.29   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Nucleotide Excision Repair
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Nucleotide Excision Repair
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (82)
1 – 10 of 82
USP7
Tchem
Family: Enzyme
Novelty: 0.00412878
Score: 0.987
Data Source: Reactome,STRINGDB
GTF2H1
Tbio
Novelty: 0.01736328
Score: 0.975
Data Source: STRINGDB
ERCC8
Tbio
Novelty: 0.02679635
Score: 0.975
Data Source: STRINGDB
DDB1
Tbio
Novelty: 0.00345896
Score: 0.967
Data Source: STRINGDB
XAB2
Tbio
Novelty: 0.04104647
Score: 0.96
Data Source: STRINGDB
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
Score: 0.959
Data Source: STRINGDB
XPA
Tbio
Novelty: 0.00137698
Score: 0.958
Data Source: STRINGDB
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
Score: 0.955
Data Source: STRINGDB
GTF2H5
Tbio
Novelty: 0.03493285
Score: 0.95
Data Source: STRINGDB
HMGN1
Tbio
Novelty: 0.00492501
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.29

PubMed score by year
PubTator Score  7.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer