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Tclin
KCNQ3
Potassium voltage-gated channel subfamily KQT member 3

Protein Summary
Description
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388996
  • ENSP00000373648
  • ENSG00000184156
  • ENST00000521134
  • ENSP00000429799

Symbol
  • EBN2
  • BFNC2
  • KV7.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.92
molecular function
0.79
gene perturbation
0.74
microRNA
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.99   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.99   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.6
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.6
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily Q member 3
VGNC:12300
464403
Macaque
potassium voltage-gated channel subfamily Q member 3
700785
Mouse
MGI:1336181
110862
Rat
RGD:69222
29682
Dog
potassium voltage-gated channel subfamily Q member 3
VGNC:42289
475103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily Q member 3
Macaque
potassium voltage-gated channel subfamily Q member 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily Q member 3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Neuronal System
Protein-Protein Interactions (185)
1 – 10 of 185
ANK3
Tbio
Novelty: 0.00429246
Score: 0.977
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.976
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.973
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.972
Data Source: STRINGDB
NFASC
Tbio
Novelty: 0.00545331
Score: 0.955
Data Source: Reactome,STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.946
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.945
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.943
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.941
Data Source: Reactome,STRINGDB
NRCAM
Tbio
Novelty: 0.00443497
Score: 0.941
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  161.99

PubMed score by year
PubTator Score  141.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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