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Tbio
IL17RE
Interleukin-17 receptor E

Protein Summary
Description
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
kinase perturbation
0.6
tissue
0.54
cell type or tissue
0.52
cell line
0.51


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 17 receptor E
698972
Mouse
MGI:1889371
57890
Rat
RGD:735148
362417
Dog
interleukin 17 receptor E
VGNC:41950
484661
Opossum
interleukin 17 receptor E
100024110
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 17 receptor E
Mouse
Rat
Dog
interleukin 17 receptor E
Opossum
interleukin 17 receptor E
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NFR9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (79)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Signaling by Interleukins
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (35)
1 – 10 of 35
GORAB
Tbio
Novelty: 0.06288992
p_int: 0.999999702
p_ni: 2.97e-7
p_wrong: 1e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
PPFIA1
Tbio
Novelty: 0.01904029
p_int: 0.999781607
p_ni: 0.000218393
Data Source: BioPlex
HMMR
Tbio
Novelty: 0.0039196
p_int: 0.999700188
p_ni: 0.000299812
Score: 0.169
Data Source: BioPlex,STRINGDB
FAM192A
Tdark
Novelty: 0.46220707
p_int: 0.983303707
p_ni: 0.016696293
Score: 0.173
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.972687382
p_ni: 0.027312618
Data Source: BioPlex
PSMG4
Tdark
Novelty: 0.05339077
p_int: 0.958095756
p_ni: 0.041904244
Score: 0.173
Data Source: BioPlex,STRINGDB
PSMG3
Tchem
Novelty: 0.01730294
p_int: 0.925402613
p_ni: 0.074597384
p_wrong: 3e-9
Data Source: BioPlex
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.907702002
p_ni: 0.092297998
Data Source: BioPlex
FAT3
Tbio
Novelty: 0.03661008
p_int: 0.822875479
p_ni: 0.177124521
Score: 0.179
Data Source: BioPlex,STRINGDB
IL17C
Tbio
Novelty: 0.00495464
Score: 0.989
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  8.55

PubMed score by year
PubTator Score  6.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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