You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FECH
Ferrochelatase, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the ferrous insertion into protoporphyrin IX. The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262093
  • ENSP00000262093
  • ENSG00000066926
  • ENST00000382873
  • ENSP00000372326

Symbol
  • EPP
  • FCE
  • EPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.93
biological process
0.9
kinase perturbation
0.84
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.42   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.42   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
63.8
mean corpuscular hemoglobin concentration
1
1
1
57.7
mean corpuscular hemoglobin
1
1
1
28.9
mean corpuscular volume
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
63.8
mean corpuscular hemoglobin concentration
1
57.7
mean corpuscular hemoglobin
1
28.9
mean corpuscular volume
1
11.2
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Protein-Protein Interactions (167)
1 – 10 of 167
ATPAF2
Tbio
Family: Enzyme
Novelty: 0.04184643
p_int: 0.999995567
p_ni: 0.000004433
Score: 0.203
Data Source: BioPlex,STRINGDB
NELFB
Tbio
Novelty: 0.05821821
p_int: 0.999994081
p_ni: 0.000005919
Score: 0.768
Data Source: BioPlex,STRINGDB
NELFCD
Tbio
Novelty: 0.00094754
p_int: 0.999990523
p_ni: 0.000009476
p_wrong: 1e-9
Score: 0.691
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999977586
p_ni: 0.000022414
Score: 0.495
Data Source: BioPlex,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.999965195
p_ni: 0.000034805
Score: 0.522
Data Source: BioPlex,STRINGDB
MMP26
Tchem
Family: Enzyme
Novelty: 0.02180874
p_int: 0.999931943
p_ni: 0.000068057
Score: 0.156
Data Source: BioPlex,STRINGDB
FMC1
Tbio
Novelty: 0.06702205
p_int: 0.999927739
p_ni: 0.000072205
p_wrong: 5.6e-8
Score: 0.305
Data Source: BioPlex,STRINGDB
TIMP2
Tbio
Family: Enzyme
Novelty: 0.00064016
p_int: 0.999849703
p_ni: 0.000150296
p_wrong: 1e-9
Score: 0.534
Data Source: BioPlex,STRINGDB
UBL4B
Tdark
Novelty: 0.56877836
p_int: 0.999623503
p_ni: 0.000376497
Data Source: BioPlex
NELFE
Tbio
Novelty: 0.02136256
p_int: 0.998892117
p_ni: 0.00110788
p_wrong: 4e-9
Score: 0.691
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  339.42

PubMed score by year
PubTator Score  466.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: