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Tclin
KCNA1
Potassium voltage-gated channel subfamily A member 1

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382545
  • ENSP00000371985
  • ENSG00000111262

Symbol
  • EA1
  • MK1
  • AEMK
  • HBK1
  • HUK1
  • MBK1
  • RBK1
  • KV1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.89
gene perturbation
0.85
molecular function
0.84
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.15   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 541.15   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (49)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (293)
1 – 10 of 293
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.995
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.992
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.973
Data Source: STRINGDB
CNTNAP1
Tbio
Novelty: 0.00618741
Score: 0.886
Data Source: STRINGDB
CACNA1A
Tchem
Family: IC
Novelty: 0.00069217
Score: 0.798
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.792
Data Source: STRINGDB
KCNA3
Tclin
Family: IC
Novelty: 0.00169224
Score: 0.789
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score  541.15

PubMed score by year
PubTator Score  334.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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