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Tbio
GPR78
G-protein coupled receptor 78

Protein Summary
Description
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382487
  • ENSP00000371927
  • ENSG00000155269
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
cell line
0.46
tissue
0.42
chemical
0.41
phenotype
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.14   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.14   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
70.2
body height
1
1
1
57.1
body fat distribution
1
1
2
42.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
70.2
body height
1
57.1
body fat distribution
2
42.2
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (19)
1 – 10 of 19
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
Score: 0.8
Data Source: STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.681
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.567
Data Source: STRINGDB
UTS2R
Tchem
Family: GPCR
Novelty: 0.00865846
Score: 0.561
Data Source: STRINGDB
ATF6
Tbio
Family: TF
Novelty: 0.00149266
Score: 0.513
Data Source: STRINGDB
GPR61
Tbio
Family: GPCR
Novelty: 0.11649666
Score: 0.509
Data Source: STRINGDB
GPR62
Tbio
Family: GPCR
Novelty: 0.43474185
Score: 0.488
Data Source: STRINGDB
XBP1
Tchem
Family: TF
Novelty: 0.00095584
Score: 0.469
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.451
Data Source: STRINGDB
DDIT3
Tbio
Novelty: 0.00116135
Score: 0.448
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.14

PubMed score by year
PubTator Score  8.98

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer