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Tbio
MICU2
Calcium uptake protein 2, mitochondrial

Protein Summary
Description
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382374
  • ENSP00000371811
  • ENSG00000165487

Symbol
  • EFHA1
  • EFHA1
  • 1110008L20Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.88
transcription factor binding site profile
0.83
transcription factor perturbation
0.8
cellular component
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
1
1
0
1.3
54.6
PR segment
1
1
0
1.4
46.3
electrocardiography
1
1
13
37.6
heel bone mineral density
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
1.3
54.6
PR segment
0
1.4
46.3
electrocardiography
13
37.6
heel bone mineral density
1
6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uptake 2
VGNC:5077
452475
Macaque
mitochondrial calcium uptake 2
706065
Mouse
MGI:1915764
68514
Rat
RGD:619739
171433
Dog
mitochondrial calcium uptake 2
VGNC:43221
486044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uptake 2
Macaque
mitochondrial calcium uptake 2
Mouse
Rat
Dog
mitochondrial calcium uptake 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IYU8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (64)
1 – 10 of 64
MICU1
Tbio
Novelty: 0.00984731
p_int: 0.999999997
p_ni: 3e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
ACOX3
Tbio
Family: Enzyme
Novelty: 0.04077258
p_int: 0.999991377
p_ni: 0.000008622
p_wrong: 1e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
KLHL22
Tbio
Novelty: 0.24456252
p_int: 0.999617418
p_ni: 0.000382582
Data Source: BioPlex
SMAP1
Tbio
Novelty: 0.41009464
p_int: 0.998893694
p_ni: 0.001098328
p_wrong: 0.000007978
Score: 0.234
Data Source: BioPlex,STRINGDB
TBC1D22A
Tbio
Novelty: 0.46374046
p_int: 0.992635611
p_ni: 0.007364388
Score: 0.562
Data Source: BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
p_int: 0.978328121
p_ni: 0.021671861
p_wrong: 1.8e-8
Data Source: BioPlex
CPLX4
Tdark
Novelty: 0.1755035
p_int: 0.975558543
p_ni: 0.024441455
p_wrong: 2e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.97270252
p_ni: 0.027297477
p_wrong: 3e-9
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.968503622
p_ni: 0.031496377
p_wrong: 1e-9
Data Source: BioPlex
TRIM44
Tbio
Novelty: 0.00483553
p_int: 0.961624167
p_ni: 0.038375832
Data Source: BioPlex
Publication Statistics
PubMed Score  20.59

PubMed score by year
PubTator Score  12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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