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Tbio
FGF9
Fibroblast growth factor 9

Protein Summary
Description
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382353
  • ENSP00000371790
  • ENSG00000102678

Symbol
  • GAF
  • FGF-9
  • SYNS3
  • HBFG-9
  • HBGF-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.82
transcription factor binding site profile
0.81
gene perturbation
0.8
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.04   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 375   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.04   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
97.6
dehydroepiandrosterone sulphate measurement
1
4
5
79.9
corneal topography
1
1
1
18.7
systolic blood pressure
1
1
1
8.7
sex hormone-binding globulin measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
97.6
dehydroepiandrosterone sulphate measurement
5
79.9
corneal topography
1
18.7
systolic blood pressure
1
8.7
sex hormone-binding globulin measurement
1
7.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 9
VGNC:13093
744731
Macaque
fibroblast growth factor 9
721324
Mouse
MGI:104723
14180
Rat
RGD:2610
25444
Dog
fibroblast growth factor 9
VGNC:40854
477340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 9
Macaque
fibroblast growth factor 9
Mouse
Rat
Dog
fibroblast growth factor 9
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31371-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (115)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 73
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (46)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (171)
1 – 10 of 171
EIF2A
Tbio
Novelty: 0.08652858
p_int: 0.995043628
p_ni: 0.003481163
p_wrong: 0.001475209
Score: 0.188
Data Source: BioPlex,STRINGDB
AFDN
Tbio
Novelty: 0.00372947
p_int: 0.993002021
p_ni: 0.00699795
p_wrong: 2.9e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
FRA10AC1
Tdark
Novelty: 0.25570773
p_int: 0.930104688
p_ni: 0.069895138
p_wrong: 1.75e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
SUPT4H1
Tbio
Novelty: 0.0127914
p_int: 0.890835018
p_ni: 0.007032544
p_wrong: 0.102132438
Score: 0.199
Data Source: BioPlex,STRINGDB
GTF2F1
Tbio
Novelty: 0.02118098
p_int: 0.876581406
p_ni: 0.123418571
p_wrong: 2.3e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
TMED7
Tdark
Novelty: 0.31193294
p_int: 0.855870576
p_ni: 0.14410832
p_wrong: 0.000021103
Score: 0.188
Data Source: BioPlex,STRINGDB
NAA15
Tbio
Family: Enzyme
Novelty: 0.00513055
p_int: 0.846228959
p_ni: 0.153771041
Score: 0.161
Data Source: BioPlex,STRINGDB
PPID
Tchem
Family: Enzyme
Novelty: 0.01068886
p_int: 0.796564206
p_ni: 0.057192544
p_wrong: 0.14624325
Score: 0.202
Data Source: BioPlex,STRINGDB
FGF20
Tbio
Novelty: 0.0145462
p_int: 0.779251152
p_wrong: 0.220748848
Score: 0.961
Data Source: BioPlex,STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  328.04

PubMed score by year
PubTator Score  468.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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