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Tbio
MIPEP
Mitochondrial intermediate peptidase

Protein Summary
Description
Cleaves proteins, imported into the mitochondrion, to their mature size. The product of this gene performs the final step in processing a specific class of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane. This protein is primarily involved in the maturation of oxidative phosphorylation (OXPHOS)-related proteins. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382172
  • ENSP00000371607
  • ENSG00000027001

Symbol
  • MIP
  • MIP
  • HMIP
  • COXPD31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.84
transcription factor perturbation
0.8
tissue sample
0.76
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pathological myopia
1
1
0
1.3
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pathological myopia
0
1.3
86.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial intermediate peptidase
VGNC:5078
467228
Macaque
mitochondrial intermediate peptidase
707131
Mouse
MGI:1917728
70478
Rat
RGD:621680
81684
Dog
mitochondrial intermediate peptidase
VGNC:43242
477338
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial intermediate peptidase
Macaque
mitochondrial intermediate peptidase
Mouse
Rat
Dog
mitochondrial intermediate peptidase
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (80)
1 – 10 of 80
CDC42SE1
Tdark
Novelty: 0.02176417
p_int: 0.99996217
p_ni: 0.00003783
Score: 0.214
Data Source: BioPlex,STRINGDB
MGME1
Tbio
Family: Enzyme
Novelty: 0.05284418
p_int: 0.999880923
p_ni: 0.000119077
Score: 0.201
Data Source: BioPlex,STRINGDB
FOXRED2
Tdark
Family: Enzyme
Novelty: 0.33139597
p_int: 0.999761336
p_ni: 0.000238664
Score: 0.158
Data Source: BioPlex,STRINGDB
JTB
Tbio
Novelty: 0.06646216
p_int: 0.999567031
p_ni: 0.000432969
Data Source: BioPlex
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.999247863
p_ni: 0.000752137
Score: 0.165
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
p_int: 0.999217811
p_ni: 0.000782189
Data Source: BioPlex
SPINK2
Tdark
Family: Enzyme
Novelty: 0.06832697
p_int: 0.99905188
p_ni: 0.00094812
Data Source: BioPlex
STPG1
Tbio
Novelty: 0.14438047
p_int: 0.998954296
p_ni: 0.001045649
p_wrong: 5.5e-8
Data Source: BioPlex
INA
Tbio
Novelty: 0.00708581
p_int: 0.998265147
p_ni: 0.001734853
Data Source: BioPlex
FOXS1
Tbio
Family: TF
Novelty: 0.17661517
p_int: 0.99820314
p_ni: 0.00179686
Score: 0.534
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.04

PubMed score by year
PubTator Score  23.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer