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Tbio
SGCZ
Zeta-sarcoglycan

Protein Summary
Description
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382080
  • ENSP00000371512
  • ENSG00000185053

Symbol
  • ZSG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
cell type or tissue
0.77
phenotype
0.75
disease
0.64
cellular component
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
6
8
98.1
cognitive function measurement
3
2
3
95.1
intelligence
3
5
1
6.6
95
body mass index
3
2
3
93.3
self reported educational attainment
3
4
4
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
8
98.1
cognitive function measurement
3
95.1
intelligence
1
6.6
95
body mass index
3
93.3
self reported educational attainment
4
91.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan zeta
VGNC:14585
472703
Macaque
sarcoglycan zeta
100430474
Mouse
MGI:2388820
244431
Dog
sarcoglycan zeta
VGNC:49686
482890
Opossum
sarcoglycan zeta
100014044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcoglycan zeta
Macaque
sarcoglycan zeta
Mouse
Dog
sarcoglycan zeta
Opossum
sarcoglycan zeta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96LD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
RANGRF
Tbio
Family: Enzyme
Novelty: 0.02750539
p_int: 0.999992685
p_ni: 0.00000607
p_wrong: 0.000001245
Score: 0.169
Data Source: BioPlex,STRINGDB
SP3
Tbio
Family: TF
Novelty: 0.00119924
p_int: 0.999900626
p_ni: 0.000099356
p_wrong: 1.8e-8
Score: 0.297
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.998889199
p_ni: 0.001107327
p_wrong: 0.000003474
Score: 0.721
Data Source: BioPlex,STRINGDB
GNPTAB
Tbio
Family: Enzyme
Novelty: 0.00336101
p_int: 0.99699528
p_ni: 0.00300472
Score: 0.157
Data Source: BioPlex,STRINGDB
HARS
Tchem
Family: Enzyme
Novelty: 0.01271582
p_int: 0.971870221
p_ni: 0.028129779
Score: 0.534
Data Source: BioPlex,STRINGDB
SGCB
Tbio
Novelty: 0.00970061
p_int: 0.971548086
p_ni: 0.028451914
Score: 0.955
Data Source: BioPlex,STRINGDB
ACACA
Tchem
Family: Enzyme
Novelty: 0.00248313
p_int: 0.928173054
p_ni: 0.071826946
Score: 0.187
Data Source: BioPlex,STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
p_int: 0.903942131
p_ni: 0.096057869
Data Source: BioPlex
ATP5PB
Tbio
Family: Enzyme
Novelty: 0.07345384
p_int: 0.877662431
p_ni: 0.122337569
Data Source: BioPlex
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.800815448
p_ni: 0.199140176
p_wrong: 0.000044376
Data Source: BioPlex
Publication Statistics
PubMed Score  12.91

PubMed score by year
PubTator Score  8.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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