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Tbio
CLEC6A
C-type lectin domain family 6 member A

Protein Summary
Description
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (PubMed:28652405). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity). The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382073
  • ENSP00000371505
  • ENSG00000205846

Symbol
  • CLECSF10
  • DECTIN2
  • CLEC4N
  • CLECSF10
  • dectin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
microRNA
0.77
cell line
0.61
transcription factor perturbation
0.61
cell type or tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.65   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.65   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Immune System
Innate Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (47)
1 – 10 of 47
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.971
Data Source: Reactome,STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.941
Data Source: Reactome,STRINGDB
CLEC4E
Tchem
Novelty: 0.00793367
Score: 0.923
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.917
Data Source: Reactome,STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.91
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.903
Data Source: Reactome,STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.795
Data Source: STRINGDB
CARD9
Tbio
Family: Enzyme
Novelty: 0.00547101
Score: 0.793
Data Source: STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.707
Data Source: STRINGDB
CLEC12A
Tbio
Novelty: 0.01478908
Score: 0.7
Data Source: STRINGDB
Publication Statistics
PubMed Score  89.65

PubMed score by year
PubTator Score  27.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer