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Tbio
RSAD2
Radical S-adenosyl methionine domain-containing protein 2

Protein Summary
Description
Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382040
  • ENSP00000371471
  • ENSG00000134321

Symbol
  • CIG5
  • cig5
  • vig1
  • cig33
  • 2510004L01Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.98
transcription factor perturbation
0.96
biological process
0.84
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.76   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.76   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
radical S-adenosyl methionine domain containing 2
VGNC:10754
459006
Macaque
radical S-adenosyl methionine domain containing 2
708720
Mouse
MGI:1929628
58185
Rat
RGD:620495
65190
Dog
radical S-adenosyl methionine domain containing 2
VGNC:45770
609005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
radical S-adenosyl methionine domain containing 2
Macaque
radical S-adenosyl methionine domain containing 2
Mouse
Rat
Dog
radical S-adenosyl methionine domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXG1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (54)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Protein-Protein Interactions (200)
1 – 10 of 200
SCNM1
Tbio
Novelty: 0.19700548
p_int: 0.99987424
p_ni: 0.000124912
p_wrong: 8.48e-7
Score: 0.403
Data Source: BioPlex,STRINGDB
UBAC1
Tbio
Novelty: 0.00122518
p_int: 0.904061165
p_ni: 0.095894782
p_wrong: 0.000044053
Score: 0.239
Data Source: BioPlex,STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.997
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.997
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.997
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.995
Data Source: STRINGDB
IFIT2
Tbio
Novelty: 0.01023074
Score: 0.994
Data Source: STRINGDB
OAS1
Tbio
Family: Enzyme
Novelty: 0.00532331
Score: 0.993
Data Source: STRINGDB
MX2
Tbio
Novelty: 0.00139073
Score: 0.993
Data Source: STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  196.76

PubMed score by year
PubTator Score  77.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer