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Tbio
TNNI2
Troponin I, fast skeletal muscle

Protein Summary
Description
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252898
  • ENSP00000252898
  • ENSG00000130598
  • ENST00000381905
  • ENSP00000371330
  • ENST00000381906
  • ENSP00000371331
  • ENST00000381911
  • ENSP00000371336

Symbol
  • DA2B
  • FSSV
  • fsTnI
  • AMCD2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.59
disease perturbation
0.56
cellular component
0.53
tissue sample
0.53
transcription factor
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.38   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.38   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
36.5
monocyte percentage of leukocytes
2
1
2
15.6
2
1
0
1.1
13.5
2
1
0
1.1
6.8
bladder carcinoma
1
1
0
1.1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
36.5
monocyte percentage of leukocytes
2
15.6
0
1.1
13.5
0
1.1
6.8
bladder carcinoma
0
1.1
4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
troponin I2, fast skeletal type
VGNC:7695
466317
Macaque
troponin I2, fast skeletal type
721041
Mouse
MGI:105070
21953
Rat
RGD:62050
29389
Dog
troponin I2, fast skeletal type
VGNC:52055
475995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
troponin I2, fast skeletal type
Macaque
troponin I2, fast skeletal type
Mouse
Rat
Dog
troponin I2, fast skeletal type
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
NUCB2
Tbio
Novelty: 0.00831106
p_int: 0.999999991
p_ni: 9e-9
Score: 0.391
Data Source: BioPlex,STRINGDB
RFTN2
Tdark
Novelty: 0.99330616
p_int: 0.999802384
p_ni: 0.00019509
p_wrong: 0.000002525
Score: 0.214
Data Source: BioPlex,STRINGDB
KLHL21
Tbio
Novelty: 0.20694121
p_int: 0.999760359
p_ni: 0.000238169
p_wrong: 0.000001472
Score: 0.245
Data Source: BioPlex,STRINGDB
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999711041
p_ni: 0.000010915
p_wrong: 0.000278044
Data Source: BioPlex
TLE4
Tbio
Novelty: 0.02094922
p_int: 0.995455479
p_ni: 0.004544521
Score: 0.188
Data Source: BioPlex,STRINGDB
TLE1
Tbio
Novelty: 0.00594261
p_int: 0.895772821
p_ni: 0.104227179
Score: 0.239
Data Source: BioPlex,STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
p_int: 0.764885791
p_ni: 0.235114209
Score: 0.184
Data Source: BioPlex,STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
Score: 0.999
Data Source: Reactome,STRINGDB
TNNC1
Tclin
Novelty: 0.03535727
Score: 0.999
Data Source: Reactome,STRINGDB
TNNT3
Tbio
Novelty: 0.0212335
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  34.38

PubMed score by year
PubTator Score  18.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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