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Tbio
KLRC2
NKG2-C type II integral membrane protein

Protein Summary
Description
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381902
  • ENSP00000371327
  • ENSG00000205809

Symbol
  • NKG2C
  • NKG2C
  • CD159c
  • NKG2-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.64
molecular function
0.53
phenotype
0.53
biological term
0.49
tissue
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.92   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.92   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
DAP12 interactions (R-HSA-2172127)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DAP12 interactions
DAP12 signaling
Immune System
Innate Immune System
Protein-Protein Interactions (146)
1 – 10 of 146
HLA-E
Tbio
Novelty: 0.00263667
Score: 0.988
Data Source: Reactome,STRINGDB
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00522854
Score: 0.976
Data Source: Reactome,STRINGDB
B2M
Tbio
Novelty: 0.00012184
Score: 0.966
Data Source: Reactome,STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  93.92

PubMed score by year
PubTator Score  104.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer