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Tbio
SHOX
Short stature homeobox protein

Protein Summary
Description
Controls fundamental aspects of growth and development. This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334060
  • ENSP00000335505
  • ENSG00000185960
  • ENST00000381575
  • ENSP00000370987
  • ENST00000381578
  • ENSP00000370990

Symbol
  • PHOG
  • SS
  • GCFX
  • PHOG
  • SHOXY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
phenotype
0.68
microRNA
0.65
biological term
0.52
biological process
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.35   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.35   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
short stature homeobox
VGNC:46153
491706
Cow
short stature homeobox
VGNC:49963
615159
Opossum
short stature homeobox
100010575
Chicken
short stature homeobox
CGNC:50824
418669
Anole lizard
short stature homeobox
100553965
Species
Name
OMA
EggNOG
Inparanoid
Dog
short stature homeobox
Cow
short stature homeobox
Opossum
short stature homeobox
Chicken
short stature homeobox
Anole lizard
short stature homeobox
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15266-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (61)
1 – 10 of 61
ARSE
Tbio
Family: Enzyme
Novelty: 0.00151862
Score: 0.757
Data Source: STRINGDB
CD99
Tbio
Novelty: 0.00229439
Score: 0.711
Data Source: STRINGDB
SOX5
Tbio
Family: TF
Novelty: 0.00623121
Score: 0.692
Data Source: STRINGDB
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
Score: 0.66
Data Source: STRINGDB
LEUTX
Tdark
Family: TF
Novelty: 0.20538904
Score: 0.648
Data Source: STRINGDB
CLCN4
Tchem
Family: IC
Novelty: 0.01905473
Score: 0.641
Data Source: STRINGDB
SOX6
Tbio
Family: TF
Novelty: 0.00484243
Score: 0.639
Data Source: STRINGDB
PLCXD1
Tdark
Novelty: 0.30611801
Score: 0.62
Data Source: STRINGDB
GTPBP6
Tdark
Novelty: 0.05036884
Score: 0.603
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.602
Data Source: STRINGDB
Publication Statistics
PubMed Score  407.35

PubMed score by year
PubTator Score  294.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer