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Tbio
IL33
Interleukin-33

Protein Summary
Description
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381434
  • ENSP00000370842
  • ENSG00000137033
  • ENST00000417746
  • ENSP00000394039
  • ENST00000456383
  • ENSP00000414238
  • ENST00000611532
  • ENSP00000478858

Symbol
  • C9orf26
  • IL1F11
  • NFHEV
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • C9orf26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.98
gene perturbation
0.98
disease
0.66
phenotype
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1804.43   (req: < 5)
Gene RIFs: 411   (req: <= 3)
Antibodies: 993   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1804.43   (req: >= 5)
Gene RIFs: 411   (req: > 3)
Antibodies: 993   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.5
75.6
eosinophil count
2
2
2
64.6
serum metabolite measurement
2
1
2
61.7
eosinophil percentage of leukocytes
1
2
2
58
childhood onset asthma
1
1
0
1.1
32.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
75.6
eosinophil count
2
64.6
serum metabolite measurement
2
61.7
eosinophil percentage of leukocytes
2
58
childhood onset asthma
0
1.1
32.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-33 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
Immune System
Interleukin-1 family signaling
Interleukin-33 signaling
Gene Ontology Terms (28)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (176)
1 – 10 of 176
IL1RL1
Tbio
Novelty: 0.00541949
Score: 0.999
Data Source: Reactome,STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.978
Data Source: STRINGDB
USP21
Tbio
Family: Enzyme
Novelty: 0.11434352
Score: 0.968
Data Source: Reactome,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.963
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.942
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.942
Data Source: Reactome,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.939
Data Source: Reactome,STRINGDB
TSLP
Tbio
Novelty: 0.00140333
Score: 0.934
Data Source: STRINGDB
IL1RAP
Tclin
Novelty: 0.01115915
Score: 0.926
Data Source: Reactome,STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  1804.43

PubMed score by year
PubTator Score  836.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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