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Tbio
HR
Lysine-specific demethylase hairless

Protein Summary
Description
Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312841
  • ENSP00000326765
  • ENSG00000168453
  • ENST00000381418
  • ENSP00000370826

Symbol
  • AU
  • MUHH
  • ALUNC
  • HYPT4
  • MUHH1
  • HSA277165
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.66
cell type or tissue
0.6
molecular function
0.6
phenotype
0.57
disease perturbation
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.14   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.14   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HR, lysine demethylase and nuclear receptor corepressor
VGNC:864
464040
Macaque
HR, lysine demethylase and nuclear receptor corepressor
574164
Mouse
MGI:96223
15460
Rat
RGD:620634
60563
Dog
HR, lysine demethylase and nuclear receptor corepressor
VGNC:41781
486130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HR, lysine demethylase and nuclear receptor corepressor
Macaque
HR, lysine demethylase and nuclear receptor corepressor
Mouse
Rat
Dog
HR, lysine demethylase and nuclear receptor corepressor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43593-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Name
Explore in Pharos
Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Gene Ontology Terms (15)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (26)
1 – 10 of 26
RBP3
Tbio
Family: Enzyme
Novelty: 0.00204835
Score: 0.756
Data Source: STRINGDB
SFRP2
Tbio
Novelty: 0.00454703
Score: 0.646
Data Source: STRINGDB
VDR
Tclin
Family: NR
Novelty: 0.00058366
Score: 0.639
Data Source: STRINGDB
FBXO10
Tbio
Novelty: 0.18324932
Score: 0.623
Data Source: STRINGDB
MTERF2
Tbio
Novelty: 0.0942186
Score: 0.565
Data Source: STRINGDB
PRDX5
Tbio
Novelty: 0.00369421
Score: 0.527
Data Source: STRINGDB
DSG4
Tbio
Novelty: 0.01599371
Score: 0.525
Data Source: STRINGDB
JMJD8
Tbio
Novelty: 0.31175159
Score: 0.509
Data Source: STRINGDB
STX17
Tbio
Novelty: 0.01788363
Score: 0.478
Data Source: STRINGDB
KDM4D
Tchem
Family: Epigenetic
Novelty: 0.00429542
Score: 0.447
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.14

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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