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Tchem
KDM4C
Lysine-specific demethylase 4C

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381306
  • ENSP00000370707
  • ENSG00000107077
  • ENST00000381309
  • ENSP00000370710
  • ENST00000536108
  • ENSP00000440656
  • ENST00000543771
  • ENSP00000445427

Symbol
  • GASC1
  • JHDM3C
  • JMJD2C
  • KIAA0780
  • GASC1
  • JHDM3C
  • JMJD2C
  • TDRD14C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
transcription factor binding site profile
0.91
transcription factor
0.83
disease perturbation
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.29   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.29   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (69)
1 – 10 of 69
CHEMBL316034
chemical structure image
CHEMBL3769724
chemical structure image
CHEMBL3771198,CHEMBL3771180
chemical structure image
CHEMBL3770740
chemical structure image
CHEMBL3775889
chemical structure image
CHEMBL3775237
chemical structure image
CHEMBL3108958
chemical structure image
CHEMBL1230640
chemical structure image
CHEMBL3775612,CHEMBL3774834
chemical structure image
CHEMBL3786803
chemical structure image
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
91.8
mathematical ability
2
1
2
77.9
self reported educational attainment
1
1
1
61.5
age at menarche
1
2
2
59.8
cognitive function measurement
1
1
1
56.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
91.8
mathematical ability
2
77.9
self reported educational attainment
1
61.5
age at menarche
2
59.8
cognitive function measurement
1
56.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 4C
VGNC:53283
464989
Macaque
lysine demethylase 4C
715273
Mouse
MGI:1924054
76804
Rat
RGD:1307528
298144
Dog
lysine demethylase 4C
VGNC:42326
474704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 4C
Macaque
lysine demethylase 4C
Mouse
Rat
Dog
lysine demethylase 4C
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H3R0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
RHO GTPase Effectors
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (87)
1 – 10 of 87
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00142673
Score: 0.876
Data Source: STRINGDB
JMJD1C
Tbio
Family: Epigenetic
Novelty: 0.02919389
Score: 0.818
Data Source: STRINGDB
KDM3A
Tchem
Family: Epigenetic
Novelty: 0.0101705
Score: 0.808
Data Source: STRINGDB
KDM7A
Tchem
Family: Epigenetic
Novelty: 0.04113733
Score: 0.767
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.757
Data Source: Reactome,STRINGDB
EHMT2
Tchem
Family: Epigenetic
Novelty: 0.00262578
Score: 0.754
Data Source: STRINGDB
KDM6B
Tchem
Family: Epigenetic
Novelty: 0.0048959
Score: 0.746
Data Source: STRINGDB
KDM2A
Tchem
Family: Epigenetic
Novelty: 0.01990727
Score: 0.743
Data Source: STRINGDB
KDM2B
Tchem
Family: Epigenetic
Novelty: 0.01630517
Score: 0.717
Data Source: STRINGDB
PHF8
Tchem
Family: Epigenetic
Novelty: 0.01946151
Score: 0.705
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.29

PubMed score by year
PubTator Score  47.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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