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Tbio
CD99
CD99 antigen

Protein Summary
Description
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381187
  • ENSP00000370582
  • ENSG00000002586
  • ENST00000381192
  • ENSP00000370588
  • ENST00000482405
  • ENSP00000494027
  • ENST00000611428
  • ENSP00000479999
  • ENST00000623253
  • ENSP00000485545

Symbol
  • MIC2
  • MIC2X
  • MIC2Y
  • MIC2
  • HBA71
  • MIC2X
  • MIC2Y
  • MSK5X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.85
transcription factor perturbation
0.84
biological term
0.72
cellular component
0.67
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.78   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 1542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.78   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 1542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
0.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD99 antigen
751057
Macaque
CD99 molecule (Xg blood group)
720563
Rat
RGD:1594332
652929
Dog
CD99 molecule
VGNC:54127
609832
Cow
CD99 molecule
VGNC:50554
509230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD99 antigen
Macaque
CD99 molecule (Xg blood group)
Rat
Dog
CD99 molecule
Cow
CD99 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14209-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Hemostasis
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (60)
1 – 10 of 60
CD99L2
Tbio
Novelty: 0.11041595
Score: 0.911
Data Source: Reactome,STRINGDB
PILRA
Tbio
Novelty: 0.05154386
Score: 0.9
Data Source: Reactome,STRINGDB
XG
Tdark
Novelty: 0.10977081
Score: 0.8
Data Source: STRINGDB
EWSR1
Tbio
Novelty: 0.00068411
Score: 0.789
Data Source: STRINGDB
ENO2
Tbio
Family: Enzyme
Novelty: 0.00016748
Score: 0.739
Data Source: STRINGDB
STS
Tchem
Family: Enzyme
Novelty: 0.00324549
Score: 0.717
Data Source: STRINGDB
ARSH
Tbio
Family: Enzyme
Novelty: 0.03202479
Score: 0.717
Data Source: STRINGDB
ARSF
Tbio
Family: Enzyme
Novelty: 0.13109678
Score: 0.712
Data Source: STRINGDB
SHOX
Tbio
Family: TF
Novelty: 0.00259568
Score: 0.711
Data Source: STRINGDB
SYP
Tbio
Novelty: 0.00021543
Score: 0.71
Data Source: STRINGDB
Publication Statistics
PubMed Score  475.78

PubMed score by year
PubTator Score  756.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer