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Tclin
TH
Tyrosine 3-monooxygenase

Protein Summary
Description
Plays an important role in the physiology of adrenergic neurons. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333684
  • ENSP00000328814
  • ENSG00000180176
  • ENST00000352909
  • ENSP00000325951
  • ENST00000381175
  • ENSP00000370567
  • ENST00000381178
  • ENSP00000370571

Symbol
  • TYH
  • TYH
  • DYT14
  • DYT5b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
kinase
0.99
molecular function
0.95
biological term
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2440.31   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 1508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2440.31   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 1508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metirosine
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
62.6
hemoglobin measurement
2
1
2
62.6
1
1
0
5.6
37.7
hematocrit
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
62.6
hemoglobin measurement
2
62.6
0
5.6
37.7
hematocrit
1
27.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Catecholamine biosynthesis (R-HSA-209905)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Catecholamine biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Catecholamine biosynthesis
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Gene Ontology Terms (81)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (275)
1 – 10 of 275
KDM3B
Tbio
Family: Epigenetic
Novelty: 0.05322289
p_int: 0.99999982
p_ni: 1.79e-7
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
NFIC
Tbio
Family: TF
Novelty: 0.00438636
p_int: 0.999999396
p_ni: 3.71e-7
p_wrong: 2.32e-7
Score: 0.281
Data Source: BioPlex,STRINGDB
RELL1
Tbio
Novelty: 0.28949625
p_int: 0.999990475
p_ni: 0.000009336
p_wrong: 1.89e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
DNAJC12
Tbio
Novelty: 0.05214775
p_int: 0.999989971
p_ni: 0.000010029
Score: 0.186
Data Source: BioPlex,STRINGDB
ZBTB34
Tdark
Family: TF
Novelty: 0.5693361
p_int: 0.999969092
p_ni: 8.32e-7
p_wrong: 0.000030075
Score: 0.199
Data Source: BioPlex,STRINGDB
MTFR2
Tbio
Novelty: 0.20272025
p_int: 0.999933769
p_ni: 0.00006621
p_wrong: 2.1e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
p_int: 0.999518484
p_ni: 0.000481515
Score: 0.169
Data Source: BioPlex,STRINGDB
TAOK2
Tchem
Family: Kinase
Novelty: 0.0232708
p_int: 0.994501834
p_ni: 0.005444694
p_wrong: 0.000053472
Score: 0.188
Data Source: BioPlex,STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
p_int: 0.909738913
p_ni: 0.090261085
p_wrong: 2e-9
Score: 0.172
Data Source: BioPlex,STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  2440.31

PubMed score by year
PubTator Score  1083.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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