You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MTIF3
Translation initiation factor IF-3, mitochondrial

Protein Summary
Description
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381116
  • ENSP00000370508
  • ENSG00000122033
  • ENST00000381120
  • ENSP00000370512
  • ENST00000405591
  • ENSP00000384659

Symbol
  • IF3mt
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.7
histone modification site profile
0.67
tissue sample
0.63
transcription factor
0.58
cell type or tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
5
8
98
red blood cell distribution width
2
2
2
65.6
body height
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
98
red blood cell distribution width
2
65.6
body height
1
3.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial translational initiation factor 3
VGNC:5081
452504
Macaque
mitochondrial translational initiation factor 3
710571
Mouse
MGI:1923616
76366
Rat
RGD:1592673
684274
Dog
mitochondrial translational initiation factor 3
VGNC:43476
477328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial translational initiation factor 3
Macaque
mitochondrial translational initiation factor 3
Mouse
Rat
Dog
mitochondrial translational initiation factor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2K0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation initiation
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation initiation
Translation
Protein-Protein Interactions (210)
1 – 10 of 210
MRPS9
Tdark
Novelty: 0.22906484
Score: 0.992
Data Source: STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
Score: 0.991
Data Source: STRINGDB
MRPS10
Tdark
Novelty: 0.21019943
Score: 0.99
Data Source: STRINGDB
MRPS15
Tdark
Novelty: 0.37070563
Score: 0.989
Data Source: STRINGDB
MRPS5
Tbio
Novelty: 0.11423336
Score: 0.989
Data Source: STRINGDB
MTIF2
Tbio
Novelty: 0.06681774
Score: 0.988
Data Source: Reactome,STRINGDB
MRPS6
Tbio
Novelty: 0.15569626
Score: 0.988
Data Source: STRINGDB
MRPS16
Tbio
Novelty: 0.24108603
Score: 0.985
Data Source: STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
Score: 0.985
Data Source: STRINGDB
MRPS12
Tbio
Novelty: 0.15394123
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.32

PubMed score by year
PubTator Score  10.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer