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Tbio
NFIB
Nuclear factor 1 B-type

Protein Summary
Description
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380953
  • ENSP00000370340
  • ENSG00000147862
  • ENST00000380959
  • ENSP00000370346
  • ENST00000543693
  • ENSP00000442888

Symbol
  • CTF
  • MACID
  • NF1-B
  • NFI-B
  • NFIB2
  • NFIB3
  • NF-I/B
  • NFI-RED
  • HMGIC/NFIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
disease perturbation
0.97
virus perturbation
0.88
trait
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.05   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.05   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Termination
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (71)
1 – 10 of 71
NFIA
Tbio
Family: TF
Novelty: 0.0104601
p_int: 0.999999292
p_wrong: 7.08e-7
Score: 0.793
Data Source: BioPlex,STRINGDB
NFIX
Tbio
Family: TF
Novelty: 0.0121925
p_int: 0.999998384
p_wrong: 0.000001616
Score: 0.704
Data Source: BioPlex,STRINGDB
NFIC
Tbio
Family: TF
Novelty: 0.00237013
p_int: 0.997310668
p_ni: 5.4e-8
p_wrong: 0.002689278
Score: 0.514
Data Source: BioPlex,STRINGDB
POLR2F
Tbio
Family: Enzyme
Novelty: 0.06393085
Score: 0.905
Data Source: STRINGDB
POLR3G
Tbio
Family: Enzyme
Novelty: 0.058744
Score: 0.901
Data Source: STRINGDB
CRCP
Tbio
Family: Enzyme
Novelty: 0.01140443
Score: 0.9
Data Source: STRINGDB
POLR2H
Tbio
Family: Enzyme
Novelty: 0.06263034
Score: 0.9
Data Source: STRINGDB
POLR1D
Tbio
Novelty: 0.02859451
Score: 0.9
Data Source: STRINGDB
POLR2L
Tbio
Family: Enzyme
Novelty: 0.06102568
Score: 0.9
Data Source: STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.16129032
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.05

PubMed score by year
PubTator Score  92.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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