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Tbio
FOXC1
Forkhead box protein C1

Protein Summary
Description
DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176). Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Acts also a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380874
  • ENSP00000370256
  • ENSG00000054598
  • ENST00000645831
  • ENSP00000493906

Symbol
  • FKHL7
  • FREAC3
  • ARA
  • IGDA
  • IHG1
  • ASGD3
  • FKHL7
  • IRID1
  • RIEG3
  • FREAC3
  • FREAC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
biological process
0.99
gene perturbation
0.94
phenotype
0.84
disease
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.91   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.91   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
WikiPathways
Heart Development
WikiPathways
BMP Signaling Pathway in Eyelid Development
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Endoderm Differentiation
Heart Development
BMP Signaling Pathway in Eyelid Development
Gene Ontology Terms (71)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (107)
1 – 10 of 107
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.10054323
p_int: 0.999290818
p_ni: 0.000709181
p_wrong: 1e-9
Score: 0.317
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01296563
p_int: 0.998684262
p_ni: 0.00131573
p_wrong: 8e-9
Data Source: BioPlex
HSPBP1
Tbio
Novelty: 0.01599246
p_int: 0.961552578
p_ni: 0.038447396
p_wrong: 2.6e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
METTL6
Tdark
Family: Enzyme
Novelty: 0.53333333
p_int: 0.927713014
p_ni: 0.07227317
p_wrong: 0.000013816
Score: 0.219
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00100906
p_int: 0.847147104
p_ni: 0.151034295
p_wrong: 0.001818601
Data Source: BioPlex
GATA3
Tbio
Family: TF
Novelty: 0.00087325
Score: 0.838
Data Source: STRINGDB
PITX2
Tbio
Family: TF
Novelty: 0.00196459
Score: 0.828
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.0000974
Score: 0.756
Data Source: STRINGDB
FLNA
Tbio
Novelty: 0.00038205
Score: 0.732
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00057391
Score: 0.7
Data Source: STRINGDB
Publication Statistics
PubMed Score  240.91

PubMed score by year
PubTator Score  179.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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