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Tbio
CNTLN
Centlein

Protein Summary
Description
Required for centrosome cohesion and recruitment of CEP68 to centrosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380641
  • ENSP00000370015
  • ENSG00000044459
  • ENST00000380647
  • ENSP00000370021

Symbol
  • C9orf101
  • C9orf39
  • C9orf39
  • C9orf101
  • bA340N12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.84
kinase perturbation
0.81
cellular component
0.79
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
87.3
alcohol use disorder measurement
1
1
0
5.9
55.2
high density lipoprotein cholesterol measurement
1
1
1
16.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
87.3
alcohol use disorder measurement
0
5.9
55.2
high density lipoprotein cholesterol measurement
1
16.2
Protein-Protein Interactions (111)
1 – 10 of 111
LAS2
Tbio
Novelty: 0.1135067
p_int: 1
Score: 0.371
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.999995434
p_ni: 5.6e-8
p_wrong: 0.00000451
Score: 0.189
Data Source: BioPlex,STRINGDB
ATG101
Tbio
Novelty: 0.03407206
p_int: 0.999994303
p_ni: 0.000005534
p_wrong: 1.63e-7
Data Source: BioPlex
TPM1
Tbio
Novelty: 0.00261206
p_int: 0.984421545
p_ni: 4.44e-7
p_wrong: 0.015578012
Score: 0.213
Data Source: BioPlex,STRINGDB
SPATC1
Tdark
Novelty: 0.26477487
Score: 0.925
Data Source: STRINGDB
LRRC45
Tdark
Novelty: 0.38407505
Score: 0.804
Data Source: STRINGDB
PCNT
Tbio
Novelty: 0.00369505
Score: 0.792
Data Source: STRINGDB
CEP170
Tbio
Novelty: 0.05342931
Score: 0.754
Data Source: STRINGDB
CROCC
Tbio
Novelty: 0.03718561
Score: 0.75
Data Source: STRINGDB
NUP85
Tbio
Novelty: 0.02350514
Score: 0.749
Data Source: STRINGDB
Publication Statistics
PubMed Score  130.22

PubMed score by year
PubTator Score  15.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer