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Tbio
GEMIN8
Gem-associated protein 8

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380523
  • ENSP00000369895
  • ENSG00000046647
  • ENST00000398355
  • ENSP00000381398

Symbol
  • FAM51A1
  • FAM51A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.83
disease perturbation
0.74
tissue sample
0.71
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (9)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (86)
1 – 10 of 86
GEMIN6
Tbio
Novelty: 0.02104816
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.999999944
p_ni: 5.6e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
GEMIN7
Tbio
Novelty: 0.04835353
p_int: 0.999999736
p_ni: 2.63e-7
p_wrong: 2e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.999998595
p_ni: 0.000001405
Score: 0.656
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.99999239
p_ni: 0.00000761
Score: 0.994
Data Source: BioPlex,STRINGDB
CPNE7
Tbio
Novelty: 0.0748235
p_int: 0.999865237
p_ni: 0.000134762
p_wrong: 1e-9
Data Source: BioPlex
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.999534782
p_ni: 0.000465218
Score: 0.958
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.999527639
p_ni: 0.000472361
Score: 0.955
Data Source: BioPlex,STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
p_int: 0.999291504
p_ni: 0.000707997
p_wrong: 4.99e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
LSM7
Tbio
Novelty: 0.09112723
p_int: 0.999176691
p_ni: 0.000821881
p_wrong: 0.000001428
Data Source: BioPlex
Publication Statistics
PubMed Score  5.20

PubMed score by year
PubTator Score  4.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer