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Tbio
CLTRN
Collectrin

Protein Summary
Description
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323). This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380342
  • ENSP00000369699
  • ENSG00000147003

Symbol
  • TMEM27
  • NX17
  • NX-17
  • TMEM27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.06   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.06   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Peptide hormone metabolism
Protein-Protein Interactions (33)
1 – 10 of 33
INS
Tbio
Novelty: 0.00000499
Score: 0.937
Data Source: STRINGDB
BACE2
Tchem
Family: Enzyme
Novelty: 0.00559862
Score: 0.841
Data Source: STRINGDB
SLC6A19
Tchem
Family: Transporter
Novelty: 0.01581031
Score: 0.823
Data Source: STRINGDB
SLC6A18
Tbio
Family: Transporter
Novelty: 0.1198606
Score: 0.657
Data Source: STRINGDB
C1QTNF12
Tbio
Novelty: 0.0694377
Score: 0.621
Data Source: STRINGDB
SNAPIN
Tbio
Novelty: 0.02019383
Score: 0.61
Data Source: STRINGDB
CTSE
Tchem
Family: Enzyme
Novelty: 0.00432129
Score: 0.579
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.568
Data Source: STRINGDB
SLC5A2
Tclin
Family: Transporter
Novelty: 0.00066797
Score: 0.543
Data Source: STRINGDB
MEP1B
Tbio
Novelty: 0.02706573
Score: 0.535
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.06

PubMed score by year
PubTator Score  23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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