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Tbio
HBD
Hemoglobin subunit delta

Protein Summary
Description
Involved in oxygen transport from the lung to the various peripheral tissues. The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380299
  • ENSP00000369654
  • ENSG00000223609
  • ENST00000643122
  • ENSP00000494708
  • ENST00000650601
  • ENSP00000497529
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
gene perturbation
0.57
molecular function
0.56
disease
0.51
cell line
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 469.57   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 469.57   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hemoglobin E disease
1
1
0
4
78.8
red blood cell distribution width
1
1
1
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hemoglobin E disease
0
4
78.8
red blood cell distribution width
1
41.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit delta
VGNC:3253
748577
Mouse
MGI:5474852
100503605
Rat
RGD:1595848
361619
Horse
hemoglobin, beta
100054109
Cow
hemoglobin, beta
280813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit delta
Mouse
Rat
Horse
hemoglobin, beta
Cow
hemoglobin, beta
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02042-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
UPF3A
Tbio
Novelty: 0.01431609
p_int: 0.999978689
p_ni: 0.000021311
Score: 0.219
Data Source: BioPlex,STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999725676
p_ni: 0.000274324
Score: 0.201
Data Source: BioPlex,STRINGDB
TNFSF8
Tbio
Novelty: 0.01292216
p_int: 0.98025264
p_ni: 0.019370862
p_wrong: 0.000376498
Data Source: BioPlex
HBA1
Tclin
Novelty: 0.00094113
Score: 0.994
Data Source: STRINGDB
HBG1
Tbio
Novelty: 0.00384136
Score: 0.963
Data Source: STRINGDB
AHSP
Tbio
Novelty: 0.00996928
Score: 0.963
Data Source: STRINGDB
HBG2
Tbio
Novelty: 0.01145628
Score: 0.954
Data Source: STRINGDB
HBZ
Tbio
Novelty: 0.00331625
Score: 0.944
Data Source: STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.924
Data Source: STRINGDB
NFE2
Tbio
Family: TF
Novelty: 0.00321017
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  469.57

PubMed score by year
PubTator Score  25.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer