You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HBG2
Hemoglobin subunit gamma-2

Protein Summary
Description
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336906
  • ENSP00000338082
  • ENSG00000196565

Symbol
  • TNCY
  • HBG-T1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.76
small molecule perturbation
0.66
tissue
0.6
protein domain
0.58
cellular component
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fetal hemoglobin measurement
2
2
2
97.6
red blood cell distribution width
3
3
3
91.3
1
1
0
2.2
82.5
mean corpuscular hemoglobin concentration
1
1
1
64
hemoglobin measurement
2
2
1
2
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fetal hemoglobin measurement
2
97.6
red blood cell distribution width
3
91.3
0
2.2
82.5
mean corpuscular hemoglobin concentration
1
64
hemoglobin measurement
1
2
62.1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P69892-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
CCNY
Tbio
Novelty: 0.01400663
p_int: 0.999938568
p_ni: 0.000061045
p_wrong: 3.87e-7
Data Source: BioPlex
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.997069239
p_ni: 0.002908722
p_wrong: 0.000022039
Data Source: BioPlex
TTC19
Tbio
Novelty: 0.08251578
p_int: 0.996940154
p_ni: 0.003059846
Data Source: BioPlex
MICAL1
Tbio
Family: Enzyme
Novelty: 0.02668048
p_int: 0.992077895
p_ni: 0.00791936
p_wrong: 0.000002745
Data Source: BioPlex
UBB
Tbio
Novelty: 0.00661254
p_int: 0.987000036
p_ni: 0.012990552
p_wrong: 0.000009411
Data Source: BioPlex
GNAZ
Tbio
Novelty: 0.02008523
p_int: 0.985125023
p_ni: 0.01486951
p_wrong: 0.000005467
Data Source: BioPlex
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.934581641
p_ni: 0.065417299
p_wrong: 0.00000106
Score: 0.192
Data Source: BioPlex,STRINGDB
PAG1
Tbio
Novelty: 0.01390911
p_int: 0.862238853
p_ni: 0.13188697
p_wrong: 0.005874177
Data Source: BioPlex
NAA16
Tbio
Family: Enzyme
Novelty: 0.23261397
p_int: 0.811855903
p_ni: 0.050075364
p_wrong: 0.138068732
Data Source: BioPlex
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.786393455
p_ni: 0.213606545
Score: 0.193
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  76.34

PubMed score by year
PubTator Score  2128.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: