Tbio KL Klotho

Protein Summary

Description

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UEF7
• Q5VZ95
• Q96KV5
• Q96KW5
• Q9UEI9
• Q9Y4F0

Gene Name

• KL

Ensembl ID

• ENST00000380099
• ENSP00000369442
• ENSG00000133116

Symbol

• HFTC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.96
molecular function	0.84
protein domain	0.73
disease	0.72
histone modification site profile	0.7

Protein Classes

PANTHER Classes

Protein / ... / Glycosidase / Klotho

DTO Classes

Protein / Enzyme / Hydrolase / Glycosidase / Klotho

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1448.7   (req: < 5)

Gene RIFs: 468   (req: <= 3)

Antibodies: 357   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1448.7   (req: >= 5)

Gene RIFs: 468   (req: > 3)

Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0