Protein Classes
Protein Summary
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
- ENST00000379984
- ENSP00000369320
- ENSG00000102104
- XLRS1
- RS
- XLRS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.78 | ||
molecular function | 0.67 | ||
biological term | 0.63 | ||
microRNA | 0.62 | ||
gene perturbation | 0.61 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 140.8 (req: < 5)
Gene RIFs: 66 (req: <= 3)
Antibodies: 74 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 140.8 (req: >= 5)
Gene RIFs: 66 (req: > 3)
Antibodies: 74 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (1)
WikiPathways (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | RAC1/PAK1/p38/MMP2 Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RAC1/PAK1/p38/MMP2 Pathway | ||||
Gene Ontology Terms (16)
Functions (8)
Components (2)
Processes (6)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (50)
1 – 10 of 50
SARM1
Novelty: 0.00613619
Score: 0.928
Data Source: STRINGDB
ATP1A3
Family: Transporter
Novelty: 0.00625715
Score: 0.924
Data Source: STRINGDB
ATP1B2
Family: Transporter
Novelty: 0.03783397
Score: 0.913
Data Source: STRINGDB
ATP1A2
Family: Transporter
Novelty: 0.00678839
Score: 0.781
Data Source: STRINGDB
ATP1A1
Family: Transporter
Novelty: 0.01738545
Score: 0.76
Data Source: STRINGDB
PLIN2
Novelty: 0.00231838
Score: 0.621
Data Source: STRINGDB
AIPL1
Novelty: 0.01698342
Score: 0.609
Data Source: STRINGDB
NR2E3
Family: NR
Novelty: 0.00182518
Score: 0.599
Data Source: STRINGDB
CDKL5
Family: Kinase
Novelty: 0.00566067
Score: 0.596
Data Source: STRINGDB
ABCA4
Family: Transporter
Novelty: 0.00172679
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score 140.80
PubMed score by year
PubTator Score 429.37
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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