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Tbio
RS1
Retinoschisin

Protein Summary
Description
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379984
  • ENSP00000369320
  • ENSG00000102104

Symbol
  • XLRS1
  • RS
  • XLRS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
molecular function
0.67
biological term
0.63
microRNA
0.62
gene perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.8   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.8   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (50)
1 – 10 of 50
SARM1
Tbio
Novelty: 0.00613619
Score: 0.928
Data Source: STRINGDB
ATP1A3
Tclin
Family: Transporter
Novelty: 0.00625715
Score: 0.924
Data Source: STRINGDB
ATP1B2
Tclin
Family: Transporter
Novelty: 0.03783397
Score: 0.913
Data Source: STRINGDB
ATP1A2
Tclin
Family: Transporter
Novelty: 0.00678839
Score: 0.781
Data Source: STRINGDB
ATP1A1
Tclin
Family: Transporter
Novelty: 0.01738545
Score: 0.76
Data Source: STRINGDB
PLIN2
Tbio
Novelty: 0.00231838
Score: 0.621
Data Source: STRINGDB
AIPL1
Tbio
Novelty: 0.01698342
Score: 0.609
Data Source: STRINGDB
NR2E3
Tbio
Family: NR
Novelty: 0.00182518
Score: 0.599
Data Source: STRINGDB
CDKL5
Tchem
Family: Kinase
Novelty: 0.00566067
Score: 0.596
Data Source: STRINGDB
ABCA4
Tbio
Family: Transporter
Novelty: 0.00172679
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score  140.80

PubMed score by year
PubTator Score  429.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer