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Tbio
DDX58
Probable ATP-dependent RNA helicase DDX58

Protein Summary
Description
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379883
  • ENSP00000369213
  • ENSG00000107201

Symbol
  • RIG1
  • RIGI
  • RIG-I
  • RLR-1
  • SGMRT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
protein domain
0.92
biological process
0.9
gene perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 946.38   (req: < 5)
Gene RIFs: 331   (req: <= 3)
Antibodies: 593   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 946.38   (req: >= 5)
Gene RIFs: 331   (req: > 3)
Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (22)
1 – 5 of 22
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
ISG15 antiviral mechanism
Gene Ontology Terms (41)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (322)
1 – 10 of 322
MAVS
Tbio
Novelty: 0.00214049
Score: 0.999
Data Source: Reactome,STRINGDB
ISG15
Tbio
Novelty: 0.00256125
Score: 0.998
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00132895
Score: 0.996
Data Source: Reactome,STRINGDB
IFIT1
Tbio
Novelty: 0.00862855
Score: 0.996
Data Source: STRINGDB
TRIM25
Tbio
Family: Enzyme
Novelty: 0.00363028
Score: 0.995
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.995
Data Source: Reactome,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00150228
Score: 0.993
Data Source: Reactome,STRINGDB
MX1
Tbio
Novelty: 0.00081841
Score: 0.993
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.00041067
Score: 0.992
Data Source: STRINGDB
RNF135
Tbio
Family: Enzyme
Novelty: 0.0446139
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  946.38

PubMed score by year
PubTator Score  648.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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