Tbio INSL3 Insulin-like 3

Protein Classes

DTO Classes

Insulin-like 3

Protein Summary

Description

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• P51460
• B4DZ72
• G3XAG0
• Q3KPI5
• Q3KPI6
• Q6YNB5
• Q9UEA2
• Q9UPH6

Gene Name

• INSL3

Ensembl ID

• ENST00000317306
• ENSP00000321724
• ENSG00000248099
• ENST00000379695
• ENSP00000369017

Symbol

• RLF
• RLNL
• RLF
• RLNL
• ley-I-L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.75
biological term	0.72
PubMedID	0.64
tissue sample	0.57
disease perturbation	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.72   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.72   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (11)

Reactome (8)

KEGG (2)

WikiPathways (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (13)

Functions (5)

Components (2)

Processes (6)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB
G protein-coupled receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
insulin receptor binding	Traceable Author Statement (TAS)	ProtInc
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc
hormone activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (162)

Explore Interacting Targets

1 – 10 of 162

• See Interactions on String-DB

MTERF4

Tbio

Novelty: 0.21242356

p_int: 0.999982617

p_ni: 0.000017274

p_wrong: 1.09e-7

Score: 0.261

Data Source: BioPlex,STRINGDB

NSUN4

Tbio

Family: Enzyme

Novelty: 0.42211055

p_int: 0.999679967

p_ni: 0.000320029

p_wrong: 4e-9

Score: 0.209

Data Source: BioPlex,STRINGDB

RNF123

Tbio

Family: Enzyme

Novelty: 0.04581752

p_int: 0.974728482

p_ni: 0.025271518

Score: 0.529

Data Source: BioPlex,STRINGDB

IREB2

Tbio

Novelty: 0.00409023

p_int: 0.970086677

p_ni: 0.029878484

p_wrong: 0.000034839

Score: 0.219

Data Source: BioPlex,STRINGDB

UBAC1

Tbio

Novelty: 0.00195339

p_int: 0.927875625

p_ni: 0.072124375

p_wrong: 1e-9

Score: 0.489

Data Source: BioPlex,STRINGDB

CHAF1B

Tbio

Novelty: 0.07516336

p_int: 0.901943541

p_ni: 0.098056459

Score: 0.513

Data Source: BioPlex,STRINGDB

GAPDHS

Tbio

Family: Enzyme

Novelty: 0.01313187

p_int: 0.828979926

p_ni: 0.171019899

p_wrong: 1.75e-7

Score: 0.156

Data Source: BioPlex,STRINGDB

RXFP2

Tbio

Family: GPCR

Novelty: 0.01111071

Score: 0.997

Data Source: Reactome,STRINGDB

RXFP1

Tchem

Family: GPCR

Novelty: 0.00590091

Score: 0.983

Data Source: STRINGDB

RLN3

Tbio

Novelty: 0.01243441

Score: 0.978

Data Source: STRINGDB

Publication Statistics

PubMed Score  266.72

PubMed score by year

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PubTator Score  182.74

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWL

1-70

ERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY

70-131

MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Hormone
Polymorphism
Reference proteome