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Tbio
EXOSC9
Exosome complex component RRP45

Protein Summary
Description
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243498
  • ENSP00000243498
  • ENSG00000123737
  • ENST00000379663
  • ENSP00000368984

Symbol
  • PMSCL1
  • p5
  • p6
  • PCH1D
  • RRP45
  • PMSCL1
  • Rrp45p
  • PM/Scl-75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
histone modification site profile
0.85
hub protein
0.85
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.56   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.56   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
67.3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
exosome component 9
707368
Mouse
MGI:1355319
50911
Rat
RGD:1307888
294975
Dog
exosome component 9
VGNC:40529
476093
Horse
exosome component 9
VGNC:17738
100063958
Species
Name
OMA
EggNOG
Inparanoid
Macaque
exosome component 9
Mouse
Rat
Dog
exosome component 9
Horse
exosome component 9
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q06265-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Protein-Protein Interactions (231)
1 – 10 of 231
C1D
Tbio
Novelty: 0.00997109
p_int: 0.987437388
p_ni: 0.012562612
Score: 0.999
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.984401354
p_ni: 0.015598646
Score: 0.998
Data Source: BioPlex,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.969980804
p_ni: 0.030019196
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.966517988
p_ni: 0.033482012
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.874434215
p_ni: 0.125565785
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC1
Tbio
Novelty: 0.01386842
p_int: 0.867653306
p_ni: 0.132346694
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC10
Tbio
Novelty: 0.00335571
Score: 0.999
Data Source: STRINGDB
DIS3L
Tdark
Family: Enzyme
Novelty: 0.12886408
Score: 0.999
Data Source: STRINGDB
DIS3
Tbio
Family: Enzyme
Novelty: 0.00961238
Score: 0.999
Data Source: STRINGDB
EXOSC5
Tbio
Family: Enzyme
Novelty: 0.03352493
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.56

PubMed score by year
PubTator Score  112.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer