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Tbio
EIF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

Protein Summary
Description
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379607
  • ENSP00000368927
  • ENSG00000173674

Symbol
  • EIF1A
  • EIF4C
  • EIF1A
  • EIF4C
  • eIF-1A
  • eIF-4C
  • EIF1AP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
co-expressed gene
0.98
disease perturbation
0.98
virus perturbation
0.96
PubMedID
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
92.4
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Protein-Protein Interactions (324)
1 – 10 of 324
EIF1AY
Tdark
p_int: 0.999999994
p_ni: 6e-9
Data Source: BioPlex
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.934258442
p_ni: 0.065741547
p_wrong: 1.1e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
PSG1
Tbio
Novelty: 0.0239046
p_int: 0.933146926
p_ni: 0.066853074
Data Source: BioPlex
WFDC2
Tbio
Novelty: 0.0136923
p_int: 0.891409854
p_ni: 0.108590145
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
POF1B
Tbio
Novelty: 0.1232792
p_int: 0.79791015
p_ni: 0.20208985
Score: 0.192
Data Source: BioPlex,STRINGDB
PDK3
Tchem
Family: Kinase
Novelty: 0.05009442
p_int: 0.764475613
p_ni: 0.235524387
p_wrong: 1e-9
Score: 0.245
Data Source: BioPlex,STRINGDB
CRHBP
Tbio
Novelty: 0.00726484
p_int: 0.751526864
p_ni: 0.248473085
p_wrong: 5.1e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
RPS18
Tbio
Novelty: 0.00688684
Score: 0.999
Data Source: STRINGDB
RPS23
Tbio
Novelty: 0.01846154
Score: 0.998
Data Source: STRINGDB
RPS28
Tbio
Novelty: 0.03303065
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.85

PubMed score by year
PubTator Score  30.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer