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Tbio
TFAP2A
Transcription factor AP-2-alpha

Protein Summary
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of other ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319516
  • ENSP00000316516
  • ENSG00000137203
  • ENST00000379608
  • ENSP00000368928
  • ENST00000482890
  • ENSP00000418541

Symbol
  • AP2TF
  • TFAP2
  • AP-2
  • BOFS
  • AP2TF
  • TFAP2
  • AP-2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
0.96
transcription factor perturbation
0.91
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 427.17   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 509   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 427.17   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (169)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (127)
1 – 10 of 127
ACOT1
Tbio
Family: Enzyme
Novelty: 0.01211801
p_int: 0.983982663
p_ni: 0.016017337
Score: 0.695
Data Source: BioPlex,STRINGDB
TFAP2B
Tbio
Family: TF
Novelty: 0.01383202
p_int: 0.899749783
p_ni: 4.9e-8
p_wrong: 0.100250168
Score: 0.949
Data Source: BioPlex,Reactome,STRINGDB
KCTD1
Tbio
Novelty: 0.09964774
Score: 0.987
Data Source: Reactome,STRINGDB
KCTD15
Tbio
Novelty: 0.05277304
Score: 0.978
Data Source: Reactome,STRINGDB
CITED4
Tbio
Novelty: 0.08663668
Score: 0.974
Data Source: Reactome,STRINGDB
CITED2
Tbio
Novelty: 0.01028104
Score: 0.971
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.961
Data Source: Reactome,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.96
Data Source: STRINGDB
TFAP2D
Tdark
Family: TF
Novelty: 0.18255944
Score: 0.96
Data Source: STRINGDB
YY1
Tbio
Family: TF
Novelty: 0.00120891
Score: 0.96
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  427.17

PubMed score by year
PubTator Score  945.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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