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Tchem
PRNP
Major prion protein

Protein Summary
Description
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally simila ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379440
  • ENSP00000368752
  • ENSG00000171867
  • ENST00000430350
  • ENSP00000399376

Symbol
  • ALTPRP
  • PRIP
  • PRP
  • CJD
  • GSS
  • PrP
  • ASCR
  • KURU
  • PRIP
  • PrPc
  • CD230
  • AltPrP
  • p27-30
  • PrP27-30
  • PrP33-35C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase perturbation
1
transcription factor perturbation
0.98
disease perturbation
0.97
biological process
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5849.66   (req: < 5)
Gene RIFs: 584   (req: <= 3)
Antibodies: 706   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5849.66   (req: >= 5)
Gene RIFs: 584   (req: > 3)
Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
mepacrine
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sporadic Creutzfeld Jacob disease
2
2
0
1.3
93.8
KANNO antigen measurement
1
1
0
1060
50.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sporadic Creutzfeld Jacob disease
0
1.3
93.8
KANNO antigen measurement
0
1060
50.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prion protein
717859
Mouse
MGI:97769
19122
Rat
RGD:3410
24686
Dog
prion protein
VGNC:45004
485783
Horse
prion protein
VGNC:21868
100065904
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prion protein
Mouse
Rat
Dog
prion protein
Horse
prion protein
Protein Structure (53 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04156-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 53
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
NCAM signaling for neurite out-growth
NCAM1 interactions
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (153)
1 – 10 of 153
RPSA
Tbio
Novelty: 0.00250446
Score: 0.967
Data Source: STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.965
Data Source: STRINGDB
NCAM1
Tbio
Novelty: 0.00020994
Score: 0.964
Data Source: Reactome,STRINGDB
STIP1
Tbio
Novelty: 0.00590952
Score: 0.954
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.95
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.947
Data Source: STRINGDB
GPC1
Tbio
Novelty: 0.00293087
Score: 0.944
Data Source: STRINGDB
BCL2
Tclin
Novelty: 0.00608635
Score: 0.927
Data Source: STRINGDB
LAMB2
Tbio
Novelty: 0.07966931
Score: 0.902
Data Source: STRINGDB
LAMB3
Tbio
Novelty: 0.00717673
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  5849.66

PubMed score by year
PubTator Score  5269.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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