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Tbio
EDN1
Endothelin-1

Protein Summary
Description
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379375
  • ENSP00000368683
  • ENSG00000078401

Symbol
  • ET1
  • QME
  • PPET1
  • ARCND3
  • HDLCQ7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
PubMedID
1
gene perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14630.31   (req: < 5)
Gene RIFs: 675   (req: <= 3)
Antibodies: 741   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14630.31   (req: >= 5)
Gene RIFs: 675   (req: > 3)
Antibodies: 741   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
67.3
pulse pressure measurement
1
1
1
48.8
hematocrit
1
1
1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.3
pulse pressure measurement
1
48.8
hematocrit
1
36
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (38)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (466)
1 – 10 of 466
EDNRA
Tclin
Family: GPCR
Novelty: 0.00045591
Score: 0.999
Data Source: Reactome,STRINGDB
EDNRB
Tclin
Family: GPCR
Novelty: 0.00053875
Score: 0.999
Data Source: Reactome,STRINGDB
ECE1
Tchem
Family: Enzyme
Novelty: 0.00180681
Score: 0.993
Data Source: Reactome,STRINGDB
EDN2
Tbio
Novelty: 0.00203492
Score: 0.983
Data Source: STRINGDB
AGT
Tbio
Novelty: 0.00049613
Score: 0.981
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.98
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.975
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.971
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.971
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  14630.31

PubMed score by year
PubTator Score  5933.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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