You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PHEX
Phosphate-regulating neutral endopeptidase PHEX

Protein Summary
Description
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505). The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379374
  • ENSP00000368682
  • ENSG00000102174

Symbol
  • PEX
  • HYP
  • PEX
  • XLH
  • HPDR
  • HYP1
  • LXHR
  • HPDR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.6
cell type or tissue
0.59
chemical
0.58
disease
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.01   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.01   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
1
43.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphate regulating endopeptidase homolog X-linked
VGNC:14827
465533
Macaque
phosphate regulating endopeptidase homolog X-linked
697025
Mouse
MGI:107489
18675
Rat
RGD:3323
25512
Dog
phosphate regulating endopeptidase homolog X-linked
VGNC:54666
480862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphate regulating endopeptidase homolog X-linked
Macaque
phosphate regulating endopeptidase homolog X-linked
Mouse
Rat
Dog
phosphate regulating endopeptidase homolog X-linked
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P78562-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (90)
1 – 10 of 90
NAXD
Tbio
Family: Enzyme
Novelty: 0.07681941
p_int: 0.917716058
p_ni: 0.082283815
p_wrong: 1.27e-7
Score: 0.369
Data Source: BioPlex,STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.95
Data Source: STRINGDB
MEPE
Tbio
Novelty: 0.00825085
Score: 0.879
Data Source: STRINGDB
DMP1
Tbio
Novelty: 0.03114505
Score: 0.822
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.794
Data Source: STRINGDB
PEX5
Tbio
Novelty: 0.00560901
Score: 0.771
Data Source: STRINGDB
PEX13
Tbio
Novelty: 0.01777214
Score: 0.762
Data Source: STRINGDB
PEX7
Tbio
Novelty: 0.01487923
Score: 0.757
Data Source: STRINGDB
PEX12
Tbio
Novelty: 0.02252744
Score: 0.746
Data Source: STRINGDB
PEX2
Tbio
Novelty: 0.01015599
Score: 0.744
Data Source: STRINGDB
Publication Statistics
PubMed Score  400.01

PubMed score by year
PubTator Score  237.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: