Protein Summary
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000379153
- ENSP00000368450
- ENSG00000112149
- BL11
- HB15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.98 | ||
gene perturbation | 0.95 | ||
virus perturbation | 0.9 | ||
transcription factor binding site profile | 0.79 | ||
disease | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 588.58 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 863 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 588.58 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 863 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (2)
WikiPathways (2)
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Macrophage markers | ||||
WikiPathways | T-Cell antigen Receptor (TCR) Signaling Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Macrophage markers | ||||
T-Cell antigen Receptor (TCR) Signaling Pathway | ||||
Gene Ontology Terms (11)
Components (3)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (196)
1 – 10 of 196
SLC30A1
Family: Transporter
Novelty: 0.00733144
p_int: 0.999918311
p_ni: 0.000081689
Data Source: BioPlex
NDST1
Family: Enzyme
Novelty: 0.01114446
p_int: 0.999907688
p_ni: 0.000092312
Data Source: BioPlex
SLC7A2
Family: Transporter
Novelty: 0.02899779
p_int: 0.999654692
p_ni: 0.000345308
Data Source: BioPlex
UGCG
Family: Enzyme
Novelty: 0.00632743
p_int: 0.999624967
p_ni: 0.000375022
p_wrong: 1.1e-8
Data Source: BioPlex
ATP7A
Family: Enzyme
Novelty: 0.00077444
p_int: 0.999356708
p_ni: 0.000643292
Data Source: BioPlex
C1orf112
Novelty: 2
p_int: 0.997926573
p_ni: 0.002073427
Data Source: BioPlex
RADIL
Novelty: 0.19933555
p_int: 0.997491915
p_ni: 0.002439402
p_wrong: 0.000068683
Data Source: BioPlex
CERS5
Family: TF
Novelty: 0.04558376
p_int: 0.997310188
p_ni: 0.002578672
p_wrong: 0.000111139
Data Source: BioPlex
BMPR2
Family: Kinase
Novelty: 0.00191079
p_int: 0.995347583
p_ni: 0.00332471
p_wrong: 0.001327707
Data Source: BioPlex
USP8
Family: Enzyme
Novelty: 0.01519091
p_int: 0.994232288
p_ni: 0.005767532
p_wrong: 1.8e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 588.58
PubMed score by year
PubTator Score 521.27
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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