You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SDHAF1
Succinate dehydrogenase assembly factor 1, mitochondrial

Protein Summary
Description
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378887
  • ENSP00000368165
  • ENSG00000205138

Symbol
  • LYRM8
  • LYRM8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.7
transcription factor perturbation
0.68
kinase perturbation
0.66
transcription factor binding site profile
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
succinate dehydrogenase complex assembly factor 1
VGNC:2254
468843
Mouse
MGI:1915582
68332
Rat
RGD:1562079
499125
Dog
succinate dehydrogenase complex assembly factor 1
484567
Horse
succinate dehydrogenase complex assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:33867]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
succinate dehydrogenase complex assembly factor 1
Mouse
Rat
Dog
succinate dehydrogenase complex assembly factor 1
Horse
succinate dehydrogenase complex assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:33867]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A6NFY7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (65)
1 – 10 of 65
NDUFAB1
Tclin
Novelty: 0.00190242
p_int: 0.99960348
p_ni: 0.00039652
Data Source: BioPlex
SDHA
Tbio
Family: Enzyme
Novelty: 0.00223171
p_int: 0.892656208
p_ni: 0.107343792
Score: 0.897
Data Source: BioPlex,STRINGDB
SDHB
Tbio
Family: Enzyme
Novelty: 0.0010199
p_int: 0.883614403
p_ni: 0.116385597
Score: 0.947
Data Source: BioPlex,STRINGDB
SDHAF3
Tbio
Family: Enzyme
Novelty: 0.01155522
Score: 0.862
Data Source: STRINGDB
HSCB
Tbio
Novelty: 0.01330125
Score: 0.82
Data Source: STRINGDB
SDHAF2
Tbio
Family: Enzyme
Novelty: 0.00495668
Score: 0.79
Data Source: STRINGDB
ISCU
Tbio
Novelty: 0.0043097
Score: 0.752
Data Source: STRINGDB
LYRM4
Tbio
Novelty: 0.03319832
Score: 0.741
Data Source: STRINGDB
SDHD
Tbio
Family: Enzyme
Novelty: 0.00167904
Score: 0.739
Data Source: STRINGDB
SDHAF4
Tbio
Family: Enzyme
Novelty: 0.24150488
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.31

PubMed score by year
PubTator Score  5.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer