You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCDC3
Coiled-coil domain-containing protein 3

Protein Summary
Description
Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378825
  • ENSP00000368102
  • ENSG00000151468
  • ENST00000378839
  • ENSP00000368116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
PubMedID
0.64
phenotype
0.6
kinase perturbation
0.54
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.99   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.99   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
61.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
61.6
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (27)
1 – 10 of 27
COL15A1
Tbio
Novelty: 0.04078006
Score: 0.604
Data Source: STRINGDB
CHODL
Tbio
Novelty: 0.04842295
Score: 0.564
Data Source: STRINGDB
ADCY4
Tbio
Family: Enzyme
Novelty: 0.00465974
Score: 0.546
Data Source: STRINGDB
SEPHS1
Tbio
Family: Enzyme
Novelty: 0.01539662
Score: 0.543
Data Source: STRINGDB
SERTAD4
Tdark
Novelty: 0.70786986
Score: 0.536
Data Source: STRINGDB
BEND7
Tdark
Novelty: 0.5500966
Score: 0.512
Data Source: STRINGDB
SMOC2
Tbio
Novelty: 0.03698108
Score: 0.504
Data Source: STRINGDB
CAMK1D
Tchem
Family: Kinase
Novelty: 0.0274233
Score: 0.503
Data Source: STRINGDB
TSTD2
Tdark
Family: Enzyme
Novelty: 1.81982307
Score: 0.5
Data Source: STRINGDB
COCH
Tbio
Novelty: 0.00819355
Score: 0.492
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.99

PubMed score by year
PubTator Score  2.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer