You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FANCG
Fanconi anemia group G protein

Protein Summary
Description
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378643
  • ENSP00000367910
  • ENSG00000221829

Symbol
  • XRCC9
  • FAG
  • XRCC9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
disease perturbation
0.83
histone modification site profile
0.75
cellular component
0.69
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.4   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.4   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
55.7
platelet count
1
1
1
29
mean corpuscular hemoglobin concentration
1
1
1
7.8
mean corpuscular volume
1
1
1
5.8
mean reticulocyte volume
1
1
1
5.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
55.7
platelet count
1
29
mean corpuscular hemoglobin concentration
1
7.8
mean corpuscular volume
1
5.8
mean reticulocyte volume
1
5.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group G
VGNC:4696
465067
Macaque
Fanconi anemia complementation group G
698837
Mouse
MGI:1926471
60534
Rat
RGD:1587477
691105
Dog
FA complementation group G
VGNC:40722
611887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group G
Macaque
Fanconi anemia complementation group G
Mouse
Rat
Dog
FA complementation group G
Pathways (60)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (110)
1 – 10 of 110
FAAP20
Tbio
Novelty: 0.15112645
p_int: 0.999999545
p_ni: 4.32e-7
p_wrong: 2.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
FANCA
Tbio
Novelty: 0.00324947
p_int: 0.999999383
p_ni: 6.13e-7
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
GYPB
Tbio
Novelty: 0.00442195
p_int: 0.999998972
p_ni: 0.000001027
Data Source: BioPlex
DPEP1
Tclin
Family: Enzyme
Novelty: 0.00384946
p_int: 0.999996382
p_ni: 0.000003618
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.999868
p_ni: 0.000127717
p_wrong: 0.000004283
Data Source: BioPlex
UBB
Tbio
Novelty: 0.00661254
p_int: 0.995739551
p_ni: 0.004260449
Score: 0.908
Data Source: BioPlex,STRINGDB
PAPSS1
Tbio
Family: Enzyme
Novelty: 0.01784751
p_int: 0.995253851
p_ni: 0.004746149
Score: 0.226
Data Source: BioPlex,STRINGDB
CSTF2T
Tbio
Novelty: 0.11811814
p_int: 0.967240833
p_ni: 0.032759166
p_wrong: 1e-9
Score: 0.178
Data Source: BioPlex,STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.999
Data Source: STRINGDB
FANCB
Tbio
Novelty: 0.00268111
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  115.40

PubMed score by year
PubTator Score  79.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: