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Tbio
SEPHS1
Selenide, water dikinase 1

Protein Classes
Protein Summary
Description
Synthesizes selenophosphate from selenide and ATP. This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327347
  • ENSP00000367893
  • ENSG00000086475
  • ENST00000378614
  • ENSP00000367877
  • ENST00000545675
  • ENSP00000441119

Symbol
  • SELD
  • SPS
  • SPS1
  • SPS
  • SELD
  • SPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.98
molecular function
0.95
transcription factor perturbation
0.94
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.05   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.05   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
91.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
91.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (78)
1 – 10 of 78
HLX
Tbio
Family: TF
Novelty: 0.00982861
p_int: 0.986423539
p_ni: 0.013576461
Score: 0.391
Data Source: BioPlex,STRINGDB
SEPSECS
Tbio
Family: Enzyme
Novelty: 0.00698701
Score: 0.986
Data Source: STRINGDB
SCLY
Tbio
Family: Enzyme
Novelty: 0.05154464
Score: 0.958
Data Source: STRINGDB
TXNRD2
Tbio
Family: Enzyme
Novelty: 0.002052
Score: 0.93
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.927
Data Source: STRINGDB
EEFSEC
Tbio
Novelty: 0.00847753
Score: 0.925
Data Source: STRINGDB
ACADS
Tbio
Family: Enzyme
Novelty: 0.00841051
Score: 0.878
Data Source: STRINGDB
SAE1
Tbio
Novelty: 0.01613881
Score: 0.84
Data Source: STRINGDB
DUT
Tchem
Family: Enzyme
Novelty: 0.0026993
Score: 0.834
Data Source: STRINGDB
CRKL
Tbio
Novelty: 0.0051181
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.05

PubMed score by year
PubTator Score  43.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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