You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PODXL
Podocalyxin

Protein Summary
Description
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. This gene encodes a member of the sialomucin protein family. The encoded protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322985
  • ENSP00000319782
  • ENSG00000128567
  • ENST00000378555
  • ENSP00000367817

Symbol
  • PCLP
  • PCLP1
  • PC
  • PCLP
  • Gp200
  • PCLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.96
cellular component
0.92
microRNA
0.8
histone modification site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.02   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 1094   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.02   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 1094   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
6.2
alcohol dependence measurement
1
1
1
4.3
Agents acting on the renin-angiotensin system use measurement
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
6.2
alcohol dependence measurement
1
4.3
Agents acting on the renin-angiotensin system use measurement
1
0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
podocalyxin like
VGNC:8735
472604
Macaque
podocalyxin like
704777
Mouse
MGI:1351317
27205
Rat
RGD:621878
192181
Dog
podocalyxin like
VGNC:54792
482252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
podocalyxin like
Macaque
podocalyxin like
Mouse
Rat
Dog
podocalyxin like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00592-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Primary Focal Segmental Glomerulosclerosis FSGS
WikiPathways
Hepatitis C and Hepatocellular Carcinoma
WikiPathways
Ectoderm Differentiation
Name
Explore in Pharos
Explore in Source
Primary Focal Segmental Glomerulosclerosis FSGS
Hepatitis C and Hepatocellular Carcinoma
Ectoderm Differentiation
Gene Ontology Terms (24)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (94)
1 – 10 of 94
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999992129
p_ni: 0.000007871
Data Source: BioPlex
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999991394
p_ni: 0.000008605
p_wrong: 1e-9
Score: 0.873
Data Source: BioPlex,STRINGDB
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.999988454
p_ni: 0.000011546
Data Source: BioPlex
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.999965094
p_ni: 0.000034906
Data Source: BioPlex
FCN1
Tbio
Novelty: 0.01037775
p_int: 0.999947112
p_ni: 0.000052888
Score: 0.188
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999939026
p_ni: 0.000060969
p_wrong: 6e-9
Score: 0.292
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999937068
p_ni: 0.000062217
p_wrong: 7.15e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
RHPN1
Tbio
Novelty: 0.05722992
p_int: 0.99985101
p_ni: 0.000148971
p_wrong: 1.9e-8
Data Source: BioPlex
HSPA12A
Tbio
Novelty: 0.11999085
p_int: 0.999577225
p_ni: 0.000422775
Score: 0.162
Data Source: BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.998174982
p_ni: 0.001825018
Score: 0.154
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  355.02

PubMed score by year
PubTator Score  194.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: