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Tchem
LPAR6
Lysophosphatidic acid receptor 6

Protein Summary
Description
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345941
  • ENSP00000344353
  • ENSG00000139679
  • ENST00000378434
  • ENSP00000367691
  • ENST00000620633
  • ENSP00000482660

Symbol
  • P2RY5
  • LAH3
  • P2Y5
  • ARWH1
  • HYPT8
  • P2RY5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
PubMedID
0.86
transcription factor perturbation
0.8
small molecule perturbation
0.69
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.17   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.17   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
64.5
monocyte count
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
64.5
monocyte count
1
21
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Nucleotide-like (purinergic) receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Nucleotide-like (purinergic) receptors
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (225)
1 – 10 of 225
DMD
Tclin
Novelty: 0.00025661
p_int: 0.998391692
p_ni: 0.001593147
p_wrong: 0.000015161
Score: 0.161
Data Source: BioPlex,STRINGDB
FAM126A
Tbio
Novelty: 0.0250547
p_int: 0.995413311
p_ni: 0.002861509
p_wrong: 0.001725179
Score: 0.159
Data Source: BioPlex,STRINGDB
PKP2
Tbio
Novelty: 0.00493803
p_int: 0.99084065
p_ni: 0.00915935
Data Source: BioPlex
LMBRD2
Tdark
Novelty: 0.60495132
p_int: 0.979694017
p_ni: 0.020289809
p_wrong: 0.000016174
Data Source: BioPlex
PTPRD
Tbio
Family: Enzyme
Novelty: 0.01059407
p_int: 0.970597174
p_ni: 0.029393316
p_wrong: 0.00000951
Data Source: BioPlex
SFXN5
Tdark
Novelty: 0.30379915
p_int: 0.968158836
p_ni: 0.031054958
p_wrong: 0.000786206
Data Source: BioPlex
MTX3
Tdark
Novelty: 0.06082176
p_int: 0.967025903
p_ni: 0.032974097
Data Source: BioPlex
ATL3
Tbio
Novelty: 0.05295598
p_int: 0.944079768
p_ni: 0.055920066
p_wrong: 1.66e-7
Data Source: BioPlex
RAB32
Tbio
Family: Enzyme
Novelty: 0.02514559
p_int: 0.943676917
p_ni: 0.054385453
p_wrong: 0.00193763
Data Source: BioPlex
STX10
Tbio
Novelty: 0.05193552
p_int: 0.942707654
p_ni: 0.057221856
p_wrong: 0.00007049
Data Source: BioPlex
Publication Statistics
PubMed Score  56.17

PubMed score by year
PubTator Score  56.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer